Research Overview

The long-term research programme of the laboratory has been focused on studying the structure-function relationships of microtubule proteins and their interactions with other cytoskeletal elements in cells under normal and pathological conditions. The organization of dynamic microtubule networks is controlled by microtubule organizing centres (MTOCs). One of the key components of MTOCs is γ-tubulin, which is necessary for nucleation of microtubules. Current work focuses on the understanding of the modulation of microtubule properties by signal transduction molecules, the function of γ-tubulin forms, and molecular and functional characterization of regulators of microtubule nucleation. To address these questions, techniques of molecular biology, biochemistry and immunology are being used, as well as a variety of microscopic techniques, including live cell imaging and quantification of microtubule nucleation and plus end dynamics.

More...

News and updates

  • 24th Cytoskeletal Club

    18-20 May, 2016

    More...

  • Mast cells (book chapter)

    pdf

    More...

  • 23rd Cytoskeletal Club

    20-22 May, 2015

    More...

  • Basophils and Mast Cells (book chapter)

    pdf

    More...

  • 22nd Cytoskeletal Club

    21-23 May, 2014

    More...

  • Deciphering new molecular mechanisms of mast cell activation (book chapter)

    pdf

    More...

  • Protein downstream processing (book chapter)

    pdf

    More...

  • 21st Cytoskeletal Club

    15-17 May, 2013

    More...

  • COST-Action BM1007, Mast Cells and Basophils

    19-20 May, 2012

  • 20th Cytoskeletal Club

    16-18 May, 2012

    More...

  • The Cytoskeleton and Human Disease (book chapter)

    pdf

    More...

  • Journal of Neuropathology and Experimental Neurology (cover)

    pdf

  • Journal of Cellular Physiology (cover)

    pdf

  • Plant Cell (cover)

    pdf

  • Plant Cell (cover)

    pdf

Welcome to Pavel Dráber Lab
header_img.png