Research Overview
The long-term research programme of the laboratory has been focused on studying the structure-function relationships of microtubule proteins and their interactions with other cytoskeletal elements in cells under normal and pathological conditions. The organization of dynamic microtubule networks is controlled by microtubule organizing centres (MTOCs). One of the key components of MTOCs is γ-tubulin, which is necessary for nucleation of microtubules. Current work focuses on the understanding of the modulation of microtubule properties by signal transduction molecules, the function of γ-tubulin forms, and molecular and functional characterization of regulators of microtubule nucleation. To address these questions, techniques of molecular biology, biochemistry and immunology are being used, as well as a variety of microscopic techniques, including live cell imaging and quantification of microtubule nucleation and plus end dynamics.
News and updates
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Journal of Cellular Physiology (cover)
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Life Science Alliance (cover)
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Advanced Materials (cover)
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COST-Action BM1007, Mast Cells and Basophils
19-20 May, 2012
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Journal of Neuropathology and Experimental Neurology (cover)
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Journal of Cellular Physiology (cover)
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Plant Cell (cover)
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Plant Cell (cover)
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Application of Optical Engineering to the Study of Cellular Pathology (book chapter)
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